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Avoid alcohol, other central nervous system depressants, driving and operating machinery, grapefruit and grapefruit juice, and overdose of acetaminophen while taking hydrocodone
These substances can increase the risk of side effects such as drowsiness, dizziness, impaired judgment, excessive sedation, respiratory depression, and overdose.
It is illegal to share medication with others, so be cautious when taking it in higher doses or more frequently than prescribed.
Misuse and sharing can lead to liver damage and be dangerous and illegal.
Do not exceed the recommended daily dose of acetaminophen if taking a combination product that contains the medication.
What drugs can interact with Hydrocodone?
Hydrocodone can interact with other drugs, potentially affecting its effectiveness and increasing the risk of side effects or complications.
It can be combined with other central nervous system depressants, alcohol, monoamine oxidase inhibitors (MAOIs), serotonin-sensitive medications, CYP3A4 inhibitors and inducers, and drugs that affect liver function.
Certain medications that increase serotonin levels, such as SSRIs and SNRIs, can cause serious adverse reactions, including serotonin syndrome.
Xanax, Valium, sedatives, muscle relaxants, and certain antidepressants can potentiate the sedative effects and increase the risk of respiratory depression and overdose.
Grapefruit and grapefruit juice can inhibit metabolism and potentially enhance its effects or cause adverse reactions.
Medications affecting liver function, including certain antibiotics, antifungals, and medications metabolized by the liver, can also impact metabolism and increase toxicity risk.
Hydrocodone is a safe and effective pain management tool, but patients should follow their healthcare provider's instructions and explore alternative options.
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