Remdesivir is a prodrug form of the antiviral nucleoside analog GS-441524.Which is upon entry into cells, remdesivir is metabolized into a nucleoside monophosphate form, which is further metabolized to an active nucleoside triphosphate that induces RNA chain termination and inhibits viral polymerases.3 Remdesivir reduces viral titers in primary human airway epithelial (HAE) cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV) or severe acute respiratory syndrome CoV (SARS-CoV; EC50s = 0.074 and 0.069 µM, respectively).
It reduces infectious virus production in SARS-CoV-2-infected HAE cells (EC50 = 10 nM).4 In vivo, remdesivir (25 and 50 mg/kg) reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection.2 Remdesivir (25 mg/kg) also reduces lung viral titers and lung hemorrhage and improves pulmonary function in mice infected with a chimeric SARS-CoV encoding the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp).4 Formulations containing remdesivir have been used in the treatment of COVID-19.
Remdesivir is a major benefit of remdesivir in comparison with other antiviral nucleoside analogs is its resistance to proofreading exonucleases, which occur in coronaviruses.
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Zhejiang mytic Biotechnology Co., Ltd., founded in january2015, is a biotechnology company mainly engaged in the research of traditional Chinese medicine and animal placenta, with a registered capital of 10 million and a total assets of nearly 100 million. Its subordinate nuobelon engineering technology research and development center and modern production plant of traditional Chinese veterinary edicine; Veterinary medicine production plant is mainly engaged in the development and production of traditional Chinese medicine extraction, chemical medicine and environmental purification agent, some of which are leading in the preparation industry.
Factory Add : 223 Chuangye Road, Nanhu Industrial Park, Jiaxing City, Zhejiang Province
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Last Update : 13 May 2021 1:19 PM
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